Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response

Author(s): Roberta Ranieri, Chiara Laezza, Maurizio Bifulco, Daniela Marasco, Anna M. Malfitano.

Journal Name: Recent Patents on CNS Drug Discovery (Discontinued)

Volume 10 , Issue 2 , 2015

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Abstract:

Background: Cannabinoid receptors are involved in the neuro-pathogenic mechanisms of inflammatory conditions of the central nervous system and their expression can be modulated during diseases.

Methods: In this manuscript we highlight the function of cannabinoid receptors, their signalling and expression at peripheral and central levels in order to understand their implication in neuro-inflammation and review the effects of cannabinoids in neuro-inflammatory disorders.

Results: Brain inflammatory processes are characterized by infiltration of numerous types of cells: both peripheral and brain resident immune cells and other neuronal cells. The disruption of the blood brain barrier favours cell infiltration in the central nervous system with consequent neuronal damage, a common event in many neuro-inflammatory diseases. Cannabinoids affect brain adaptive and immune response, regulate inflammatory mediators and can exert a role in blood brain barrier damage prevention.

Conclusion: Various patents describe the beneficial properties of cannabinoids in numerous neurodegenerative diseases with inflammatory components and overall effects support the therapeutic application of cannabinoids.

Keywords: Cannabinoids, cannabinoid receptors, neuro-inflammation, immune response, blood brain barrier, brain, neurode generative diseases.

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2015
Page: [178 - 203]
Pages: 26
DOI: 10.2174/1574889810666160620103725
Price: $58

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