Abstract
Resveratrol (3,4,5'-trihydroxy-trans-stilibene) is a famous natural product which exhibits potential antitumor activity both in vitro and in vivo. In this article, A series of formamide derivatives of resveratrol (C1-27) were synthesized and their cytotoxic activities were evaluated, with results indicating that most of the compounds exhibited antitumor activity against both Smmc7721 and SGC7901 cancer cell lines. Among them, compound C21 displayed the most potent antitumor activities, with IC50 values of 7.68 and 6.16 M against Smmc7721 and SGC7901 cancer cell lines respectively. All compounds reported herein were characterized by 1H NMR, 13C NMR, MS and IR spectrum. Additionally, the structure of compound C10 was confirmed by X-ray crystallographic analysis.
Keywords: Resveratrol, formamide derivatives, synthesis, characterization, single-crystal x-ray diffraction, antitumor activity.
Letters in Drug Design & Discovery
Title:Formamide Derivatives of Resveratrol: Synthesis, Characterization and Cytotoxicity
Volume: 13 Issue: 6
Author(s): Hai-Jun Ni, Hui-Jie Cheng, Wei-Wei Ge, Meng-Xue Lin, Qing-Shan Li and Ban-Feng Ruan
Affiliation:
Keywords: Resveratrol, formamide derivatives, synthesis, characterization, single-crystal x-ray diffraction, antitumor activity.
Abstract: Resveratrol (3,4,5'-trihydroxy-trans-stilibene) is a famous natural product which exhibits potential antitumor activity both in vitro and in vivo. In this article, A series of formamide derivatives of resveratrol (C1-27) were synthesized and their cytotoxic activities were evaluated, with results indicating that most of the compounds exhibited antitumor activity against both Smmc7721 and SGC7901 cancer cell lines. Among them, compound C21 displayed the most potent antitumor activities, with IC50 values of 7.68 and 6.16 M against Smmc7721 and SGC7901 cancer cell lines respectively. All compounds reported herein were characterized by 1H NMR, 13C NMR, MS and IR spectrum. Additionally, the structure of compound C10 was confirmed by X-ray crystallographic analysis.
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Cite this article as:
Ni Hai-Jun, Cheng Hui-Jie, Ge Wei-Wei, Lin Meng-Xue, Li Qing-Shan and Ruan Ban-Feng, Formamide Derivatives of Resveratrol: Synthesis, Characterization and Cytotoxicity, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/157018081306160618153304
DOI https://dx.doi.org/10.2174/157018081306160618153304 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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