Background: In tissue engineering applications, advanced membrane systems provide useful and
adaptable biomimetic microenvironment able to sustain cell viability and functions, enabling the delivery and
diffusion of biochemical factors, cell nutrients, and products, and mimicking the natural biological extracellular
matrix. Proper cell-material interactions favour cell adhesion and trigger cell growth, migration, proliferation,
differentiation and functional activation. The wide availability of biocompatible polymers offers the possibility
to develop membranes with tuned morphological, physico-chemical, mechanical and transport properties
for targeted tissues.
Objective: In this review, an in-depth examination of how the membrane properties are able to influence and
direct the cellular morpho-functional behaviour of specific engineered tissues is discussed. Furthermore, an
overview of the advanced membrane systems, in different configuration and composition, for the biofabrication
of tissues and organs is reported.