Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach

Author(s): Tim Lekic , Damon Klebe , Pilar Pichon , Katarina Brankov , Sally Sultan , Devin McBride , Darlene Casel , Alhamza Al-Bayati , Yan Ding , Jiping Tang , John H. Zhang* .

Journal Name: Current Drug Targets

Volume 18 , Issue 12 , 2017

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Abstract:

Background: Germinal matrix hemorrhage is a leading cause of mortality and morbidity from prematurity. This brain region is vulnerable to bleeding and re-bleeding within the first 72 hours of preterm life. Cerebroventricular expansion of blood products contributes to the mechanisms of brain injury. Consequences include lifelong hydrocephalus, cerebral palsy, and intellectual disability. Unfortunately little is known about the therapeutic needs of this patient population.

Objectives: This review discusses the mechanisms of germinal matrix hemorrhage, the animal models utilized, and the potential therapeutic targets.

Conclusion: Potential therapeutic approaches identified in pre-clinical investigations include corticosteroid therapy, iron chelator administration, and transforming growth factor-β pathway modulation, which all warrant further investigation. Thus, effective preclinical modeling is essential for elucidating and evaluating novel therapeutic approaches, ahead of clinical consideration.

Keywords: Animal model, drug discovery, experimental, hydrocephalus, neurological dysfunction, translational research.

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Article Details

VOLUME: 18
ISSUE: 12
Year: 2017
Page: [1316 - 1328]
Pages: 13
DOI: 10.2174/1389450117666160615100538
Price: $58

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