Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity.
The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced
by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation,
wound healing, organogenesis and oncogenesis. Cytokines also play vital roles in the differentiation
of MSCs into several cell lineages. This review summarizes on how cytokines can affect MSCs differentiation
and their relative signaling pathways, which may serve to understand the possible underlying mechanisms.
Also, this review reveals the potential clinical use of MSCs as promising therapeutic agents due to
their special characteristics such as multipotent differentiation, immunomodulatory properties, and selfrestoration.
Keywords: Adipogenesis, chondrogenesis, immunomodulatory cytokines, mesenchymal stem cells, odontogenesis, osteogenesis.
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