Targeting Cancer Cells with Photoactive Silica Nanoparticles
This review highlights recent advances in the preparation of silica nanoparticles
(SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photodiagnostic
and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations
has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical
properties, which make them useful for photo-biomedical applications. In order
to study their photobiological properties, diverse chemical strategies involving covalent and
non-covalent bonding have been used to load photosensitizers in/on SNPs.
Keywords: Porphyrins, Phthalocyanines, Photosensitizers, Silica Nanoparticles, PDT, Cancer.
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