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Targeting Cancer Cells with Photoactive Silica Nanoparticles

Author(s): Wioleta Borzęcka, Tito Trindade, Tomás Torres, João Tomé.

Abstract:

This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photodiagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.

Keywords: Porphyrins, Phthalocyanines, Photosensitizers, Silica Nanoparticles, PDT, Cancer.

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Article Details

VOLUME: 22
ISSUE: 39
Page: [6021 - 6038]
Pages: 18
DOI: 10.2174/1381612822666160614083804
Price: $58