This study aims to evaluate the underlying mechanism of action involved in the
hypotensive effect of Chamaemulum nobile L. (Cn) aqueous extract on anesthetized Wistar rats.
Lyophilized aqueous extract was administered in the jugular vein, arterial blood pressure and heart
rate were measured in the carotide artery over 120 min of injection throughout an invasive direct
blood pressure measuring procedure.
Intravenous bolus injection of aqueous Cn extract at the doses of 50, 100 and 200 mg/kg produced a
dose dependent reduction in arterial blood pressure and heart rate (p<0.001). Specific receptor
antagonists (Phentolamine, Terazosin and Atropine) and pharmacological agents (N(omega)-Nitro-L-Arginine Methyl
Ester and Captopril) were used for determining the underlying mechanism involved in the hypotensive effect of Cn. Only
Phentolamine treatment (2 mg/kg) reduced significantly the hypotensive effect of aqueous Cn extract at a dose of 200
mg/kg. Intravenous perfusion of aqueous Cn extract caused a significant reduction of arterial blood pressure (p<0.01) and
reduced the hypertensive effect of intravenous injection of norepinephrine at a dose of 1 μg/kg.
We conclude that aqueous Cn extract exhibits a hypotensive effect which may be probably due to an alpha adrenergic
receptor blockade mechanism.
Keywords: Alpha adrenergic system, antihypertensive activity, blood pressure, cardiovascular disease, Chamaemulum nobile L.,
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