Abstract
Introduction: In recent years, numerous pharmacological approaches for the treatment of type 2 diabetes mellitus (T2DM) have become available. While all of them have proven blood glucose-lowering effects, identifying the most beneficial drug or drug combination for the treatment of an individual patient has become an increasing challenge. Several guidelines attempt to provide decision criteria based on clinical characteristics and comorbidities in patients with T2DM, however, these guidelines still leave a broad range of capabilities for pharmacological treatment escalation.
Pathophysiological Approach: Addressing the pathophysiology of T2DM might be a valuable approach for the selection and combination of different drugs that can provide the most comprehensive effects in the treatment of T2DM. Besides decreasing insulin sensitivity, a progressing imbalance in alpha and beta cell function of the Langerhans islet is a fundamental component in the complex pathophysiology of the disease.
Conclusion: Considering the effect of different pharmacological interventions on the pathophysiological components in T2DM might be an effective tool guiding to most beneficial treatments, and may lead to a more tailored pharmacological intervention in patients with T2DM. .
Keywords: Type 2 Diabetes mellitus, pathophysiology, insulin resistance, alpha cell function, beta cell function, treatment of T2DM.
Current Diabetes Reviews
Title:Pharmacological Intervention in Type 2 Diabetes Mellitus – A Pathophysiologically Reasoned Approach?
Volume: 12 Issue: 4
Author(s): Thomas Forst, Tim Heise and Leona Plum-Morschel
Affiliation:
Keywords: Type 2 Diabetes mellitus, pathophysiology, insulin resistance, alpha cell function, beta cell function, treatment of T2DM.
Abstract: Introduction: In recent years, numerous pharmacological approaches for the treatment of type 2 diabetes mellitus (T2DM) have become available. While all of them have proven blood glucose-lowering effects, identifying the most beneficial drug or drug combination for the treatment of an individual patient has become an increasing challenge. Several guidelines attempt to provide decision criteria based on clinical characteristics and comorbidities in patients with T2DM, however, these guidelines still leave a broad range of capabilities for pharmacological treatment escalation.
Pathophysiological Approach: Addressing the pathophysiology of T2DM might be a valuable approach for the selection and combination of different drugs that can provide the most comprehensive effects in the treatment of T2DM. Besides decreasing insulin sensitivity, a progressing imbalance in alpha and beta cell function of the Langerhans islet is a fundamental component in the complex pathophysiology of the disease.
Conclusion: Considering the effect of different pharmacological interventions on the pathophysiological components in T2DM might be an effective tool guiding to most beneficial treatments, and may lead to a more tailored pharmacological intervention in patients with T2DM. .
Export Options
About this article
Cite this article as:
Forst Thomas, Heise Tim and Plum-Morschel Leona, Pharmacological Intervention in Type 2 Diabetes Mellitus – A Pathophysiologically Reasoned Approach?, Current Diabetes Reviews 2016; 12 (4) . https://dx.doi.org/10.2174/1573399812666160613111959
DOI https://dx.doi.org/10.2174/1573399812666160613111959 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Lipid Metabolism in Patients with End-Stage Renal Disease: A Five Year Follow-up Study
Current Vascular Pharmacology Role of the Autonomic Nervous System in the Endothelial Dysfunction of the Metabolic Syndrome
Current Hypertension Reviews Old But Good: Modified-Release Prednisone in Rheumatoid Arthritis
Reviews on Recent Clinical Trials Nasal Polyposis: An Overview of Differential Diagnosis and Treatment
Recent Patents on Inflammation & Allergy Drug Discovery Cardioprotective Effects of Indian Gooseberry (Emblica officinalis Gaertn) and its Phytochemicals: A Review
Current Nutrition & Food Science Mild Carbohydrate Intolerance in Pregnancy
Current Diabetes Reviews Suitable Antibacterial Substances for the Treatment of Urinary Tract Infections
Anti-Infective Agents in Medicinal Chemistry Exercise and Cardiac Preconditioning Against Ischemia Reperfusion Injury
Current Cardiology Reviews Thyroid Diseases During Pregnancy: Bibliometric Analysis of Scientific Publications
Endocrine, Metabolic & Immune Disorders - Drug Targets Multiple Drug Resistance Associated with Function of ABC-Transporters in Diabetes Mellitus: Molecular Mechanism and Clinical Relevance
Infectious Disorders - Drug Targets Chemical and Genetic Engineering Strategies to Improve the Potency of Pharmaceutical Proteins and Enzymes
Current Medicinal Chemistry Islet Purification for Clinical Islet Transplantation
Current Tissue Engineering (Discontinued) Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflammation in Diabetic Mice and BV2 Cells
Current Pharmaceutical Design Mycobacterium Tuberculosis in New Biologic Era
Current Rheumatology Reviews Photodynamic Therapy and Periodontal Treatment
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) Consequences of Secondary Hyperparathyroidism on Vascular Calcification and Cardiovascular Mortality: Potential Benefit of Calcimimetics
Current Drug Therapy Difference in the Influence of the Lipid Profile as a Coronary Risk Factor in Patients with and Without Diabetes Mellitus
Vascular Disease Prevention (Discontinued) Efficacy and Cardiovascular Safety of SGLT2 Inhibitors
Current Drug Safety Endocrine Disrupting Chemical Induced “Pollution of Metabolic Pathways”: A Case of Shifting Paradigms With Implications for Vascular Diseases
Current Drug Targets Oxidative Stress and the JNK Pathway are Involved in the Development of Type 1 and Type 2 Diabetes
Current Molecular Medicine