Strategies for Increasing the Solubility and Bioavailability of Anticancer Compounds: β-Lapachone and Other Naphthoquinones

Author(s): Vitor Francisco Ferreira, Caroline Deckmann Nicoletti, Patricia Garcia Ferreira, Debor Omena Futuro, Fernando de Carvalho da Silva.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 39 , 2016

Abstract:

Quinones are among the most studied natural and synthetic products in the literature because they have considerable biological potential. These compounds exhibit activity against many microorganisms and are able to eliminate tumor cells through several mechanisms of action. Some of these compounds have become drugs that are used clinically. However, they also have problems with respect to solubility, stability and toxicity. The alternative of using controlled-release systems has been applied to quinones, with good results in some cases, indicating that these formulations may be a strategy for improving the pharmacological profile of this class of compounds.

Keywords: Anticancer compounds, β-lapachone, naphthoquinones, controlled-release systems, formulations

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Article Details

VOLUME: 22
ISSUE: 39
Year: 2016
Page: [5899 - 5914]
Pages: 16
DOI: 10.2174/1381612822666160611012532
Price: $58

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