Recently human resistance to external pathogen has led to the development of
anti-bacterial wound dress, accordingly, the development of anti-bacterial wound dress using
nano-Zinc oxide matrix has been examined. ZnO in nanoparticles morphological structure
was synthesized using hydrothermal technique and were directly immobilized into
polymer blend matrix composed of alginate-PVA. The hybrid mixture was fabricated by
casting solvent evaporation into membrane film. The influence of variable ZnO amounts
blended with the polymeric matrix in different weight ratios from 5% to 30% W/V on the
fabricated composite membrane films was examined. The mechanical properties of the
fabricated zinc oxide membranes were compared using the tensile test Machine to select
the best concentration of incorporated zinc oxide nanoparticles into the polymer blend. The
most properly prepared membrane was characterized using SEM, XRD, FT-IR and TGA.
The most proper mechanical properties of ZnO polymeric membrane nanocomposite were
recorded at blending ratio of 20% W/V. Both the XRD and FT-IR analyses indicated that
possible interaction may be established between polymers and nanoparticles above the optimum
blending ratio of 20% W/V declining the fabricated membrane mechanical properties.
The antibacterial activity of the prepared membranes was assessed qualitatively by
colony forming units (CFU) measurements. The antibacterial activity demonstrated a significant
antibacterial activity against Staphylococcus aureus and Escherichia coli. This antibacterial
activity was improved by increasing the incorporation of ZnO nanoparticle concentration
in the composite membrane.
Keywords: ZnO nanoparticles, nanocomposite membranes, Antimicrobial activity, FT-IR, ZnO.
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