Techniques of Structural Characterization of Dendrimers

Author(s): Oscar Valdés Lizama , Cristián Vilos , Esteban Durán-Lara .

Journal Name: Current Organic Chemistry

Volume 20 , Issue 24 , 2016

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Abstract:

Currently, dendrimers are molecules widely investigated due to their strong potential for biomedical (including diagnostic, drug discovery, and drug delivery platforms) and others applications. The requirements demanded by Food and Drug Administration (FDA) of a new drug application involve several analytical techniques for characterization, which allow understanding the properties of the novel platforms, and to predict their interactions with the biological environment. This work proposes a full description to perform the analytical characterization of dendrimers, including techniques for evaluating the morphology, shape, molecular weight, polydispersity, and purity; as well as methods for the synthesize and conjugation with molecules for targeting.

Keywords: Dendrimers, NMR, mass spectrometry, spectroscopy, differential scanning, rheology, scattering techniques, microscopy.

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Article Details

VOLUME: 20
ISSUE: 24
Year: 2016
Page: [2591 - 2605]
Pages: 15
DOI: 10.2174/1385272820666160608095009
Price: $58

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