Currently, dendrimers are molecules widely investigated due to their strong potential
for biomedical (including diagnostic, drug discovery, and drug delivery platforms)
and others applications. The requirements demanded by Food and Drug Administration
(FDA) of a new drug application involve several analytical techniques for characterization,
which allow understanding the properties of the novel platforms, and to predict their interactions
with the biological environment. This work proposes a full description to perform the
analytical characterization of dendrimers, including techniques for evaluating the morphology,
shape, molecular weight, polydispersity, and purity; as well as methods for the synthesize
and conjugation with molecules for targeting.
Keywords: Dendrimers, NMR, mass spectrometry, spectroscopy, differential scanning, rheology, scattering techniques, microscopy.
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