In present investigation, an innovative attempt has been made to enhance the solubility and
dissolution rate of Repaglinide (RPGD) using hydrothermally treated water insoluble dietary bamboo
fibers (HVBF) as potential nutraceutical used in the treatment of diabetes mellitus. RPGD was selected
as a model drug due to its low aqueous solubility and dissolution rate. Characterization of HVBF demonstrated
the outstanding features like high surface area, maximum drug loading and increase dissolution
rate and making HVBF as an excellent drug carrier. RHVBF (Repaglinide loaded HVBF) tablets
were prepared using direct compression method. Pre and post-compression parameters for blend and tablets were studied
and found within acceptable limits. RHVBF and tablet showed significantly improved dissolution rate, when compared
with pure crystalline RPGD, physical mixture, RVBF and commercial marketed tablet. This fact was further supported by
FT-IR, DSC, XRPD and FESEM studies followed by in-vitro drug release profile. Stability studies showed no changes after
exposing to accelerated conditions for a period of 3 months with respect to physical characteristics and in-vitro drug
release studies. In a nut shell, it can be concluded that HVBF is a novel, smart and promising carrier for poorly water
soluble drugs, when administered orally.
Keywords: Carrier, dietary fibers, dissolution rate and in-vitro release, hydrothermal method, repaglinide, tablet.
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