Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has
been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The
routes of H2 administration in animal model and human clinical studies are roughly classified into three
types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. This review discusses some of the remarkable progress that has been made in the research of H2 use for neurological
disorders, such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain disorders.
Although most neurological disorders are currently incurable, these studies suggest the clinical potential
of H2 administration for their prevention, treatment, and mitigation. Several of the potential effectors of
H2 will also be discussed, including cell signaling molecules and hormones that are responsible for
preventing oxidative stress and inflammation. Nevertheless, further investigation will be required to
determine the direct target molecule of H2.
Keywords: Brain injury, cerebrovascular disease, inflammation, molecular hydrogen, neonatal brain disorder, neurodegenerative
disorder, oxidative stress.
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