Background: Crohn's disease (CD) is a chronic, disabling and destructive condition. Half
of patients will develop some bowel damage (stricture, fistula and/or abscess). Current therapeutic
strategies failed to alter its natural history.
Objective: We explore in a review article the evolution of CD treatment over a quarter of a century
from a linear sequence of treatment intensification to a complex algorithm focused on individualized
patient care by looking beyond symptoms. Specifically we focus on evolving concepts in assessing
disease severity, selecting rigorous treatment end-targets, initiating an effective therapeutic therapy,
and managing secondary loss of response.
Results: A tight monitoring of objective signs of inflammation and a treat-to-target approach are probably
the only way to change patients' life and disease course. We now seek to optimize our therapeutic
tools according to patient profile, disease phenotype and the unique pharmacodynamics that ensues.
Conclusion: Standardizing the clinical practice of gastroenteroogists with the most current treatment
algorithm may minimize disease related complications while favouring patient’s quality of life.