Background: Polyheterocyclic compounds have numerous applications in different fields ranging
from medicinal chemistry to material science. Cascade reactions represent the most direct and efficient method
to obtain polyheterocyclic molecules with functional diversity and increased complexity. Moreover, novel
polycyclic systems can be generated which can possess interesting properties such as biological activity or
luminescence. The number of polyheterocyclic compounds obtained through cascade reactions, including
multi-component reactions, is wide and this review will be limited to polyheterocycles obtained from aromatic
N-heterocycles: pyrrole, pyrazole, triazole, pyridine, pyrimidine, indole, benzimidazole, quinoline and other
mono- or bicyclic compounds.
Objective: The review will cover the period ranging from 2006 to 2015 and will focus on processes involving
the formation of C-N bonds with the heterocyclic nitrogen.