The Purpose: The objective of this study is to explore neural correlates of Default Mode
Network (DMN) regions in children with attention deficit and hyperactivity disorder (ADHD) using
resting-state functional magnetic resonance imaging (rs-fMRI).
Methods: The study included ten children with ADHD (aged between 9 and 16) and ten agematched
controls. Four DMN regions (medial prefrontal cortex (MPFC), the posterior cingulate
cortex (PCC), left and right inferior parietal lobes (IPL) and the corresponding Broadmann areas in
each one were used as seeds and their functional connectivity with the whole brain was explored and
compared between ADHD and control groups using t-test (p<0.05).
Results: We observed that when DMN regions were selected as seeds, the connected regions were
different between two groups and were mostly in the right hemisphere in ADHD patients contrary to
the left hemisphere in the control group.
Conclusion: In conclusion, neural correlates of DMN regions differ in ADHD patients compared to
healthy controls. Our findings suggest that in ADHD patients, DMN regions show more connectivity
with the right hemisphere of the brain whereas the left hemisphere is more functionally connected
with DMN in health controls. Further research is required to explore this atypical DMN connectivity
in ADHD using larger cohort.