Congestive heart failure (CHF) is a chronic and often devastating cardiovascular
disorder with no cure. There has been much advancement in the last
two decades that has seen improvements in morbidity and mortality. Clinicians
have also noted variations in the responses to therapies. More detailed observations
also point to clusters of diseases, phenotypic groupings, unusual severity and
the rates at which CHF occurs. Medical genetics is playing an increasingly important
role in answering some of these observations. This developing field in many
respects provides more information than is currently clinically applicable. This
includes making sense of the established single gene mutations or uncommon
private mutations. In this thematic series which discusses the many factors that
could be relevant for CHF care, once established treatments are available in the communities; this
section addresses a contextual role for medical genetics.
Keywords: Congestive heart failure, genetics, indigenous australian, polymorphism, review, therapeutics.
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