Cascade Reaction in the Synthesis of Heterocyclic Natural Products

Author(s): Vaezeh Fathi Vavsari, Saeed Balalaie*.

Journal Name: Current Organic Chemistry

Volume 21 , Issue 15 , 2017

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Abstract:

Background: Cascade reactions, as an attractive branch of organic chemistry, have been the subject of intense research in the recent years. In these reactions numerous transformations occur in a single sequence, and the subsequent reactions are formed as a consequence of the functionality of the previous step. Cascade reactions are environmentally benign processes due to their one-pot procedure which accordingly proceed in a single reaction solvent, work-up, and purification step. Therefore, they are often associated with cost savings in terms of solvents, catalysts, and reagents in addition to time and effort.

Objective: In the recent years, cascade reactions have been used for the construction of complicated molecular scaffolds, especially heterocyclic natural products. Different naturally occurring compounds were synthesized through cascade (tandem) reactions; this review has been focused on the use of cascade sequences for the synthesis of heterocyclic natural products.

Keywords: Cascade reaction, tandem reaction, natural products, heterocycles, total synthesis, one-pot procedure.

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Article Details

VOLUME: 21
ISSUE: 15
Year: 2017
Page: [1393 - 1426]
Pages: 34
DOI: 10.2174/1385272820666160603114213
Price: $58

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