Background: Nucleobindin2 (NUCB2)/nesfatin-1 plays a well-established
role in homeostatic functions associated with food intake and stress integration.
Aim: This review focusses on NUCB2/nesfatin-1’s central effects on gastrointestinal
functions and will summarize the effects on food intake, motility and secretion with
focus on the upper gastrointestinal tract.
Results: We will highlight the stressors that influence brain NUCB2/nesfatin-1 expression
and discuss functional implications. In addition to traditional acute psychological and
physical stressors such as restraint stress and abdominal surgery we will look at
immunological, visceral and metabolic stressors as well as a chronic combination
stress model that have been shown to affect NUCB2/nesfatin-1 signaling and describe associated
Keywords: Brain-gut axis, corticotropin releasing factor, CRF, food intake, motility, secretion.
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