Immune Frailty and Nanomaterials: The Case of Allergies

Author(s): Martin Himly, Bettina Grotz, Marlene Sageder, Mark Geppert, Albert Duschl.

Journal Name: Current Bionanotechnology (Discontinued)

Volume 2 , Issue 1 , 2016

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Abstract:

Allergic diseases are among the most prevalent immune-mediated diseases, with incidences of well over 20% of the population in industrialized countries. Nevertheless, the question of whether allergies should be considered as a risk factor for exposure to nanomaterials has rarely been addressed. Experimental studies have attempted to improve allergy therapy by combining allergens with various nanomaterials, which may lead to a beneficial re-direction of the immune system. Binding to nanoparticles may for allergens – as for other proteins – lead to structural changes or modification of other properties. We assess here the state of knowledge about biological effects deriving from the combination of nanoparticles with allergens.

Keywords: Allergy, sensitization, effector function, allergen-specific immunotherapy, SCIT, SLIT, immunomodulation, nanomedicine.

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2016
Page: [20 - 28]
Pages: 9
DOI: 10.2174/2213529402666160601124654

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