Immunotoxicity of Metal Oxide and Metal Nanoparticles and Animal Models to Evaluate Immunotoxicity of Nanoparticles

Author(s): Han Goo Kang, Jiyoung Jang, In-Hong Choi.

Journal Name: Current Bionanotechnology (Discontinued)

Volume 2 , Issue 2 , 2016

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Abstract:

Since metal (silver and gold) and metal oxide (TiO2, ZnO, SiO2) nanoparticles (NPs) are widely used in diagnostics, therapeutics, and commercial products, specialized immuno-toxicity studies are necessary to ensure their safe use in humans. In this article, we review the immunological toxicity of engineered nanomaterials (ENMs), including metal oxide and metal NPs, and suggest animal models of immunological disease suited to study the immunological effects of NPs. Administration of NPs at subtoxic doses in animals with a background of immunological diseases, especially those with allergic or inflammatory diseases, will accelerate our understanding of the precise immunotoxicity and immunestimulatory effects of NPs following real-life exposures.

Keywords: Nanoparticles, metal, metal oxide, immunotoxicity, animal model.

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2016
Page: [84 - 90]
Pages: 7
DOI: 10.2174/2213529402666160601112729
Price: $58

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