The Amazing World of Peptide Engineering: the Example of Antimicrobial Peptides from Frogs and Their Analogues

Author(s): Aline B. Guimarães, Fabiano J.Q. Costa, Osmindo R.P. Júnior, Wagner Fontes, Mariana S. Castro.

Journal Name: Protein & Peptide Letters

Volume 23 , Issue 8 , 2016

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Abstract:

This review discusses the importance and properties of antimicrobial peptides from frogs and their synthetic analogues as potential therapeutic alternatives in fighting not only bacterial infections, but also protozoans involved with the major neglected diseases, which afflict human populations (e.g., Chagas disease, African sleeping sickness, Leishmaniasis and malaria). Here, we emphasize their multifunctional properties such as promising broad-spectrum drugs that target protozoan parasites too.

Keywords: Anurans, antimicrobial peptides, analogues, protozoa.

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Article Details

VOLUME: 23
ISSUE: 8
Year: 2016
Page: [722 - 737]
Pages: 16
DOI: 10.2174/0929866523666160530185137
Price: $58

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