Isoindole Derivatives: Propitious Anticancer Structural Motifs

Author(s): Richa Kaur Bhatia.

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 2 , 2017

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Isoindole derivatives constitute an important class of biologically active heterocyclic compounds and continue to attract considerable attention due to their diverse pharmacological profile such as, antimicrobial, anthelmintic, insecticidal, cyclooxygenase isoenzyme (COX-2) and thrombin inhibition with special emphasis on anticancer activity. This review highlights anticancer properties of isoindole derivatives and its related structures and hoping that it would further help in generation of new concepts towards rational design and development of more potent and less toxic anticancer agents.

Keywords: Anti-cancer agents, Isoindole, Isoindoline, Isoindolinone, Phthalimide, Chemotherapy.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 17
ISSUE: 2
Year: 2017
Page: [189 - 207]
Pages: 19
DOI: 10.2174/1568026616666160530154100
Price: $58

Article Metrics

PDF: 19
HTML: 4
EPUB: 1