Cyclic imides are commonly encountered structural motifs in natural and synthetic
molecules with remarkable pharmacological properties. They are also used widely for
further functionalization through various chemical transformations. Currently, renewed focus
has been devoted worldwide on this important class of compounds for their potential new
applications especially in the area of medicinal / pharmaceutical chemistry as well as in drug
discovery. Consequently, their syntheses have attracted considerable interest. Various innovative
methodologies have recently been developed in order to access and functionalize this
class of compounds. For example, the combination of classical as well as modern reactions
allowed synthetic chemists to perform the straight forward and direct synthesis of diversity
based library of compounds, often in 1-2 steps. The present report will cover the relevant and
recent advances in the field of occurrences, synthesis and chemical reactions of cyclic imides mainly from 1980
to the end of 2015.
Keywords: Cyclic imides, natural product, synthesis, reactions.
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