Frontiers in Clinical Drug Research - Anti-Cancer Agents

Frontiers in Clinical Drug Research - Anti-Cancer Agents

Volume: 3

Indexed in: EBSCO.

Frontiers in Clinical Drug Research - Anti-Cancer Agents is an eBook series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for ...
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Chemotherapeutic, Immunologic, and Molecularly Targeted Therapy for the Treatment of Advanced Melanoma

Pp. 217-270 (54)

Said C. Azoury, David M. Straughan, Robert D. Bennett and Vivek Shukla

Abstract

Over the past several decades, the incidence of melanoma has increased. Although surgery remains the primary treatment modality for localized early-stage lesions, melanoma is often diagnosed following locoregional and distant disease spread. Prognosis for advanced stage disease is dismal as one would expect; however, nowadays, the myriad of systemic therapies have allowed for improvements in disease free and overall survival. Such systemic treatment approaches include chemotherapy, immunotherapy, and molecularly targeted agents. Since the time of the approval of dacarbazine by the Food and Drug Administration for the treatment of metastatic melanoma in 1975, other agents have gained approval including interleukin-2, immune checkpoint inhibitors such as ipilimumab (anti-CTLA-4), and others. More recently, studies suggest that combination regimens of the aforementioned approaches may further improve outcomes when compared to monotherapy. Herein, the authors provide an up-to-date comprehensive review on the chemotherapeutic, immunologic, and molecularly targeted therapy approaches to the treatment of advanced melanoma.

Keywords:

Advanced Stage, Anti-PD-1, Anti-CTLA-4, Anti-PD-L1, Chemotherapy, Dacarbazine, Immune Checkpoint, Immunotherapy, Interleukin-2, Melanoma, Metastatic, Systemic, Targeted Therapy, Vaccine.

Affiliation:

10 Center Drive, Room 3W5848, Thoracic and GI Oncology Branch, Clinical Center, National Cancer Center, National Institutes of Health, Bethesda, MD-20892, USA.