There has been considerable interest in azole-containing compounds as promising antiinflammatory
agents. Designed compounds with five-membered nitrogen-containing nuclei have demonstrated
good anti-inflammatory activity, indicating their potential for the treatment of this highly irritating
condition. Pyrazoles, have attracted much more attention than other azoles, however, reports on
other azoles demonstrated that they were as effective as pyrazoles. This review describes the different
classes of azoles designed as cyclooxygenase inhibitors and the effect of different structural modifications
on their activity.
Keywords: Anti-inflammatory agents, Azoles, Imidazoles, Oxadiazoles, Oxazoles, Pyrazoles, Thiazoles, Triazoles.
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