Abstract
Background: In vivo studies are crucial for the identification of pathogenic cellular and molecular mechanisms. Animal models are especially relevant due to their systems' integrity and evaluation of multiple translational parameters.
Objective: This review presents a general panorama of the pharmacological and genetic seizure models using this species as a platform for disease modeling and accelerated drug discovery.
Method: We performed a literature review about the use of zebrafish to model seizures and epilepsy.
Conclusion: The zebrafish is a prominent model organism with considerable degree of physiological and genetic conservation especially suitable for behavioral and electrophysiological investigation of seizure mechanisms. Its sensitivity to chemoconvulsant and straightforwardness in modern genetic approaches supports its competitive contribution to epilepsy research.
Keywords: Antiepileptic drugs, drug discovery, epilepsy, genetic model, pharmacological model, seizure, zebrafish.
Current Psychopharmacology
Title:Zebrafish as a Platform for Studies on Seizures and Epilepsy
Volume: 5
Author(s): Rosane S. da Silva, Carla D. Bonan and Monica R.M. Vianna
Affiliation:
Keywords: Antiepileptic drugs, drug discovery, epilepsy, genetic model, pharmacological model, seizure, zebrafish.
Abstract: Background: In vivo studies are crucial for the identification of pathogenic cellular and molecular mechanisms. Animal models are especially relevant due to their systems' integrity and evaluation of multiple translational parameters.
Objective: This review presents a general panorama of the pharmacological and genetic seizure models using this species as a platform for disease modeling and accelerated drug discovery.
Method: We performed a literature review about the use of zebrafish to model seizures and epilepsy.
Conclusion: The zebrafish is a prominent model organism with considerable degree of physiological and genetic conservation especially suitable for behavioral and electrophysiological investigation of seizure mechanisms. Its sensitivity to chemoconvulsant and straightforwardness in modern genetic approaches supports its competitive contribution to epilepsy research.
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Cite this article as:
Silva S. da Rosane, Bonan D. Carla and Vianna R.M. Monica, Zebrafish as a Platform for Studies on Seizures and Epilepsy, Current Psychopharmacology 2016; 5 (2) . https://dx.doi.org/10.2174/2211556005666160526112030
DOI https://dx.doi.org/10.2174/2211556005666160526112030 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
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Breakthroughs in drug design, development and delivery system for the management of neuro-psychiatric disorders
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. This proposal describes the ...read more
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