Abstract
Background: In vivo studies are crucial for the identification of pathogenic cellular and molecular mechanisms. Animal models are especially relevant due to their systems' integrity and evaluation of multiple translational parameters.
Objective: This review presents a general panorama of the pharmacological and genetic seizure models using this species as a platform for disease modeling and accelerated drug discovery.
Method: We performed a literature review about the use of zebrafish to model seizures and epilepsy.
Conclusion: The zebrafish is a prominent model organism with considerable degree of physiological and genetic conservation especially suitable for behavioral and electrophysiological investigation of seizure mechanisms. Its sensitivity to chemoconvulsant and straightforwardness in modern genetic approaches supports its competitive contribution to epilepsy research.
Keywords: Antiepileptic drugs, drug discovery, epilepsy, genetic model, pharmacological model, seizure, zebrafish.
Current Psychopharmacology
Title:Zebrafish as a Platform for Studies on Seizures and Epilepsy
Volume: 5
Author(s): Rosane S. da Silva, Carla D. Bonan and Monica R.M. Vianna
Affiliation:
Keywords: Antiepileptic drugs, drug discovery, epilepsy, genetic model, pharmacological model, seizure, zebrafish.
Abstract: Background: In vivo studies are crucial for the identification of pathogenic cellular and molecular mechanisms. Animal models are especially relevant due to their systems' integrity and evaluation of multiple translational parameters.
Objective: This review presents a general panorama of the pharmacological and genetic seizure models using this species as a platform for disease modeling and accelerated drug discovery.
Method: We performed a literature review about the use of zebrafish to model seizures and epilepsy.
Conclusion: The zebrafish is a prominent model organism with considerable degree of physiological and genetic conservation especially suitable for behavioral and electrophysiological investigation of seizure mechanisms. Its sensitivity to chemoconvulsant and straightforwardness in modern genetic approaches supports its competitive contribution to epilepsy research.
Export Options
About this article
Cite this article as:
Silva S. da Rosane, Bonan D. Carla and Vianna R.M. Monica, Zebrafish as a Platform for Studies on Seizures and Epilepsy, Current Psychopharmacology 2016; 5 (2) . https://dx.doi.org/10.2174/2211556005666160526112030
DOI https://dx.doi.org/10.2174/2211556005666160526112030 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
Call for Papers in Thematic Issues
Breakthroughs in drug design, development and delivery system for the management of neuro-psychiatric disorders
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. This proposal describes the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Current Phthalocyanines Delivery Systems in Photodynamic Therapy: An Updated Review
Current Medicinal Chemistry Animal Models for the Development of New Neuropharmacological Therapeutics in the Status Epilepticus
Current Neuropharmacology Cycle Helmets for Children- Education or Enforcement?
Current Pediatric Reviews Development, Recent Achievements and Current Directions of Research into GABA Uptake Inhibitors
Current Medicinal Chemistry Inhibition of Monoamine Neurotransmitter Transporters andCentral Nervous System Stimulation Induced by Synthetic Local Anesthetics and Cocaine: A Comparative Review
Current Medicinal Chemistry - Central Nervous System Agents The Role of T-Type Calcium Channels in Epilepsy and Pain
Current Pharmaceutical Design Mitochondrial Involvement in Psychiatric Illness in Adults
Current Psychiatry Reviews Assessment and Imaging of the Cerebrovascular Glycocalyx
Current Neurovascular Research An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets REM sleep and its Loss-Associated Epigenetic Regulation with Reference to Noradrenaline in Particular
Current Neuropharmacology Retraction Notice: Potential Application of Venom Proteins in Designing of Medicines for Treating Human Neurodegenerative Disorders
Protein & Peptide Letters Nanobiotechnological Approaches Against Multidrug Resistant Bacterial Pathogens: An Update
Current Drug Metabolism Functional Interference of Dexamethasone on Some Morphine Effects:Hypothesis for the Steroid-Opioid Interaction
Recent Patents on CNS Drug Discovery (Discontinued) Hormone Replacement Therapy and Stroke
Current Vascular Pharmacology Editorial
Current Medical Imaging Insights into Anti-Trypanosomal Agents Based on Synthetic Glycoconjugates
Current Topics in Medicinal Chemistry ADP-Ribosyl Cyclase as a Therapeutic Target for Central Nervous System Diseases
Central Nervous System Agents in Medicinal Chemistry Subject Index To Volume 2
Current Drug Targets Animal Venom Peptides: Potential for New Antimicrobial Agents
Current Topics in Medicinal Chemistry Natural Products as Leads for Tuberculosis Drug Development
Current Topics in Medicinal Chemistry