1,4-Diazabicyclo[2.2.2]octanium Diacetate: As a New, Effective and Reusable Catalyst for the Synthesis of 3,4- dihydropyrimidin-2(1H)-ones and -Thiones

Author(s): Leila Zare Fekri, Mahsa Movaghari.

Journal Name: Letters in Organic Chemistry

Volume 13 , Issue 6 , 2016

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Abstract:

In this study, a new, effective and environmentally benign procedure for the synthesis of dihydropyrimidinone and thione derivatives with various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the presence of 1,4-diazabicyclo[2.2.2]octanium diacetate as a novel acidic ionic liquid, in high yield and short reaction time is reported. This method provides several advantages such as easy work-up, green, environmental friendliness and fast reaction condition along with high yields.

Keywords: Biginelli reaction, ethyl acetoacetate, ionic liquid, solvent free, thiourea, urea.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [406 - 413]
Pages: 8
DOI: 10.2174/1570178613666160524160125
Price: $58

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