Rapid and Efficient One-Pot Synthesis of 3,4-Dihydroquinoxalin-2-Amine Derivatives Catalyzed by Co3O4@SiO2 Core-Shell Nanoparticles Under Ultrasound Irradiation

Mohammad   Ali   Ghasemzadeh; Boshra      Mirhosseini-Eshkevari; Mohammad   Hossein   Abdollahi-Basir

Abstract

In this research, a general synthetic method for the synthesis of 3,4- dihydroquinoxalin-2-amine derivatives was developed using Co₃O₄@SiO₂ nanoparticles under ultrasonic irradiation. Firstly by a simple and green process, Co₃O₄@SiO₂ nanoparticles were prepared via sonication, and then these nanoparticles were used as an efficient catalyst for the synthesis of 3,4- dihydroquinoxalin-2-amines via three-component reactions of ophenylenediamines (OPDA), diverse ketones and various isocyanides in ethanol under ultrasound irradiation. The combinatorial synthesis was attained for this procedure with applying ultrasound irradiation while making use of ethanol as green ambient. The present approach offers several advantages such as high yields, environmentally benign, simple work-up, excellent yield of products and short reaction times. The nanomagnetic catalyst could be readily recovered using a simple external magnet and reused several times without any significant loss in activity. The catalyst was fully characterized by FT-IR, FE-SEM, XRD, EDX, VSM and TEM analysis.

Keywords: Multi-component reaction, Ultrasound irradiation, 3, 4-Dihydroquinoxalin-2-amines, Co₃O₄@SiO₂, Nanoparticles.

« Previous

Rights & Permissions Print Cite

Combinatorial Chemistry & High Throughput Screening

Title:Rapid and Efficient One-Pot Synthesis of 3,4-Dihydroquinoxalin-2-Amine Derivatives Catalyzed by Co₃O₄@SiO₂ Core-Shell Nanoparticles Under Ultrasound Irradiation

Volume: 19 Issue: 7

Author(s): Mohammad Ali Ghasemzadeh, Boshra Mirhosseini-Eshkevari and Mohammad Hossein Abdollahi-Basir

Affiliation:

Keywords: Multi-component reaction, Ultrasound irradiation, 3, 4-Dihydroquinoxalin-2-amines, Co₃O₄@SiO₂, Nanoparticles.

Abstract: In this research, a general synthetic method for the synthesis of 3,4- dihydroquinoxalin-2-amine derivatives was developed using Co₃O₄@SiO₂ nanoparticles under ultrasonic irradiation. Firstly by a simple and green process, Co₃O₄@SiO₂ nanoparticles were prepared via sonication, and then these nanoparticles were used as an efficient catalyst for the synthesis of 3,4- dihydroquinoxalin-2-amines via three-component reactions of ophenylenediamines (OPDA), diverse ketones and various isocyanides in ethanol under ultrasound irradiation. The combinatorial synthesis was attained for this procedure with applying ultrasound irradiation while making use of ethanol as green ambient. The present approach offers several advantages such as high yields, environmentally benign, simple work-up, excellent yield of products and short reaction times. The nanomagnetic catalyst could be readily recovered using a simple external magnet and reused several times without any significant loss in activity. The catalyst was fully characterized by FT-IR, FE-SEM, XRD, EDX, VSM and TEM analysis.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Ghasemzadeh Ali Mohammad, Mirhosseini-Eshkevari Boshra and Abdollahi-Basir Hossein Mohammad, Rapid and Efficient One-Pot Synthesis of 3,4-Dihydroquinoxalin-2-Amine Derivatives Catalyzed by Co₃O₄@SiO₂ Core-Shell Nanoparticles Under Ultrasound Irradiation, Combinatorial Chemistry & High Throughput Screening 2016; 19 (7) . https://dx.doi.org/10.2174/1386207319666160524141831

DOI https://dx.doi.org/10.2174/1386207319666160524141831	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402

About this journal

Call for Papers in Thematic Issues

Submission closes on : 01 October, 2024

Artificial Intelligence Methods for Biomedical, Biochemical and Bioinformatics Problems

Recently, a large number of technologies based on artificial intelligence have been developed and applied to solve a diverse range of problems in the areas of biomedical, biochemical and bioinformatics problems. By utilizing powerful computing resources and massive amounts of data, methods based on artificial intelligence can significantly improve the ...read more

Guest Editor(s): Yinglei Song

Submission closes on : 01 May, 2024

Eco-friendly Agents for Biological Control of Pathogenic Diseases

The discovery of an alternative biological approach to disease management includes work on medicinal products derived from natural sources as a starting point for the development of eco-friendly agents for these diseases and the injuries they cause, as well as reducing human contact with hazardous chemicals and their residues. We ...read more

Guest Editor(s): Mohamed Dkhil

Submission closes on : 31 August, 2024

Emerging trends in diseases mechanisms, noble drug targets and therapeutic strategies: focus on immunological and inflammatory disorders

Recently infectious and inflammatory diseases have been a key concern worldwide due to tremendous morbidity and mortality world Wide. Recent, nCOVID-9 pandemic is a good example for the emerging infectious disease outbreak. The world is facing many emerging and re-emerging diseases out breaks at present however, there is huge lack ...read more

Guest Editor(s): Rituraj Niranjan

Submission closes on : 29 June, 2024

Exploring Spectral Graph Theory in Combinatorial Chemistry

Scope of the Thematic Issue: Combinatorial chemistry involves the synthesis and analysis of a large number of diverse compounds simultaneously. Traditional methods rely on brute force experimentation, which can be time-consuming and resource-intensive. Spectral Graph Theory, a branch of mathematics dealing with the properties of graphs in relation to the ...read more

Guest Editor(s): Jia Bao Liu