Background and Objectives: Microcos paniculata is widely
distributed throughout the Bangladesh which belongs to the family Tiliaceae.
The present study was considered to determine anti-diarrheal, analgesic,
membrane stabilizing and thrombolytic activities with evaluation of
phytochemical nature of methanolic extract of M. paniculata steam bark.
Methods: Methanolic extract of this plant part was prepared at room
temperature and the concentrated methanolic extracts used for the
phytochemical screenings by using appropriate and proper procedure for the
investigation of phytoconstituents. The extract was then used for
investigation of in-vitro thrombolytic and membrane stabilizing activity. The in-vivo antidiarrheal
and analgesic activities were done according to the method of castor oil and acetic
acid induce writhing respectively.
Results: Phytochemical study reveal the presence of flavonoids, diterpenes, alkaloids, saponin,
tannin and phenols. During the estimation of anti-diarrheal activity plant extract showed most
significant inhibition of 63.30% and 56.70% diarrhea at 400 mg/kg and 200 mg/kg,
respectively. Analgesic test showed pain inhibition of 41.36% and 32.0% at 500 mg/kg and
250 mg/kg, respectively in contrast to standard drug (Ibuprofen) showed 46.64% inhibition of
pain. The membrane stabilizing study showed that the inhibition of hemolysis increases
respectively when the dose increased. Similar result was found in thrombolytic activity which
means that when the dose increased, the thrombolytic activity of the plant extract increased.
Conclusion: By considering this result, it can be concluded that M. paniculata may lead to find
novel drugs for cardiovascular and diarrheal patient and also bring hope for patients suffering
with diverse pain.