The Role of Tumor Associated Macrophages in the Tumor Microenvironment: Mechanism and Functions

Author(s): Jie Zhu , Qiaoming Zhi , Binhua P. Zhou , Min Tao , Jingyi Liu , Wei Li .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 16 , Issue 9 , 2016

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Abstract:

During tumor progression, several types of inflammatory cells are recruited into the tumor site, where they participate in tumor-associated inflammation, such as fibroblasts, granulocytes, lymphocytes and macrophages. Macrophages infiltrating into the tumor microenvironment are termed tumorassociated macrophages (TAMs). In response to multiple stimuli, macrophages undergo recruitment and polarization, and play an important role in further tumor development. In this article, we present a review of the mechanism of macrophage’ recruitment, and the role that TAMs play in promoting immunosuppression, tumor progress and metastasis, as well as chemoresistance and future therapeutic strategies.

Keywords: Tumor associated macrophages, tumor microenvironment, pancreatic cancer, breast cancer, lung cancer, lymphoma.

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2016
Page: [1133 - 1141]
Pages: 9
DOI: 10.2174/1871520616666160520112622
Price: $58

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