Inflammation is a common response of an individual against either exogenous or
endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the
pathogenesis of neurodegenerative disorders. Experimental evidences show how neurotransmitters,
besides their role in the synapses, play a modulatory role during immune response. Drugs used for
treatment of dementia symptoms are able to increase neurotransmitters levels, and likely to have a
modulatory role during immune response. Aim of this review is to discuss the most recent advances on
inflammation role during neurodegeneration and also to individuate the potential anti-inflammatory
role played by drugs currently used for Alzheimer’s disease treatment.
Keywords: Alzheimer’s Disease, cholinesterase inhibitors, inflammation, neurodegeneration glia, nicotinic receptor.
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