Cysteine-, Methionine- and Seleno-Cysteine-Proline Chimeras: Synthesis and Their Use in Peptidomimetics Design

Author(s): Azzurra Stefanucci, Roberto Costante, Giorgia Macedonio, Szabolcs Dvoracsko, Adriano Mollica.

Journal Name: Current Bioactive Compounds

Volume 12 , Issue 3 , 2016

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Natural sulphurated amino acids are cysteine and methionine. Their importance in biological processes is largely known. Cysteine, plays a key role due to the thiol group, which represents a nucleophilic and easily oxidizable function. Synthetic methodologies to obtain Cysteine-, Methionineand Seleno-Cysteine-Proline chimeras are strongly desirable and particularly appealing in the field of organic chemistry.

Keywords: Cysteine, methionine, seleno-cysteine proline chimeras, peptidomimetic design, χ-Space, chemical ligation.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 12
ISSUE: 3
Year: 2016
Page: [200 - 206]
Pages: 7
DOI: 10.2174/1573407212666160511162915
Price: $58

Article Metrics

PDF: 18
HTML: 3
EPUB: 1
PRC: 1