Natural sulphurated amino acids are cysteine and methionine. Their importance in biological
processes is largely known. Cysteine, plays a key role due to the thiol group, which represents a
nucleophilic and easily oxidizable function. Synthetic methodologies to obtain Cysteine-, Methionineand
Seleno-Cysteine-Proline chimeras are strongly desirable and particularly appealing in the field of
Keywords: Cysteine, methionine, seleno-cysteine proline chimeras, peptidomimetic design, χ-Space, chemical ligation.
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