Psoriasis is a common skin disorder characterized by hyper proliferation
of keratinocytes. Although the exact pathophysiology of psoriasis is not entirely
understood, immune system and its interaction with nervous system have been
postulated and investigated as the underlying mechanism. The interaction between
these two systems through cholinergic anti-inflammatory pathway and also
endocannabinoid system, may suggest cannabinoids as potential addition to antipsoriatic
Keywords: Psoriasis, immunomodulation, cannabidiol, endocannabinoids, vagal nerve stimulation.
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