Inevitable caries formation and other tooth related diseases are one of the most common factors affecting
human quality of life, as they are often followed by loss of teeth. Significant research efforts have been devoted
to establishing control and preventive solutions. It is clearly known that fluoride is one of the promising
chemical substances with anti-carious activity. The elimination of the microbial infection, especially the multispecies
infections induced by aerobic and anaerobic bacteria, is a current challenge of the endodontic therapy. Using
antibiotics or other active agents (from ions, nanoparticles to natural products) loaded in specific drug carrier
systems seems to be ideal approach in treating and controlling dental diseases, even if, the drug delivery systems
used in dental applications are less established comparing with other tissues/organs. Based on the importance of
biomedical drug delivery systems the present study aims to give a brief review on the improvements of drug delivery
systems for dental applications.
Keywords: Dentistry, drug delivery system, regeneration, restoration.
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