This article offers a review regarding current approaches in bioactive dressings design, the bioactive
components as well as the experimental models used to assess their efficiency. Wound dressings come in a variety
of materials including natural polymers and synthetic polymers manufactured into various forms, such as
foams, films, hydrocolloids, hydrogels, sponges, membranes, skin substitutes, electrospun micro and nanofibers.
Until now there is no available dressing able to meet the criteria for a fast and adequate wound healing. The
dressing material may have intrinsic wound healing activity or/and may serve as a support for the release of bioactive
compounds such as antimicrobial agents (antibiotics, antiseptics, honey, plant extracts), growth factors, insulin.
There are a lot of controversies regarding the use of antimicrobials in the wounds management. However
non - antibiotic antibacterial treatment regiments are a must due to alarming antibiotic resistance. Most of the developed
bioactive wound dressings were not tested on human patients, and may prove not applicable in clinical
settings. Therefore, appropriately designed clinical studies are necessary to establish the safety profile and the efficacy
of novel bioactive dressings, in terms of ease of use, cost-effectiveness and patient satisfaction, combined
with in depth fundamental research of the mechanisms of action of different dressing's components.