Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157


Telocytes in Cardiac Protection

Author(s): Siyi Fu, Hui Zhu, Siyi Li, Yalong Wang, Yihua Bei, Junjie Xiao.


Telocytes (TCs) are a distinct type of stromal cells with extremely thin and long prolongations called telopodes (Tps). TCs have been ubiquitously reported in almost all tissues and organs across species including heart. TCs are distinct from fibroblasts as evidenced by ultrastructural characteristics, immunohistochemistry features, gene profiles, proteome features, and miRNA signatures. By means of heterocellular junctions and extracellular vesicles, TCs may be able to regulate cardiac stem cells, angiogenesis, and anti-fibrosis. Therapeutic effects of cardiac TCs in myocardium infarction have been demonstrated. Cardiac TCs could be a source of cardiac repair and protection.

Keywords: Cardiac telocytes, cardiac protection, cardiac stem cells, angiogenesis, fibrosis, regeneration.

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Article Details

Year: 2016
Page: [390 - 394]
Pages: 5
DOI: 10.2174/1574888X1105160509234231
Price: $58