Medicinal Attributes of Imidazo[1,2-a]pyridine Derivatives: An Update

Author(s): Nisha Devi, Dharmender Singh, Ravindra K. Rawal, Jitender Bariwal, Virender Singh.

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 26 , 2016

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Abstract:

The imidazo[1,2-a]pyridine scaffold is recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules. Several commercial drugs such as Zolpidem, Olprinone, Soraprazan and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. The present manuscript represents the assimilation of literature pertaining to medicinal aspects of this pharmacophore including the structure-activity relationships.

Keywords: Imidazo[1, 2-a]pyridine, SAR, Groebke-Blackburn-Bienayme reaction, Ugi Type, Multicomponent Reaction, N-fused imidazole.

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Article Details

VOLUME: 16
ISSUE: 26
Year: 2016
Page: [2963 - 2994]
Pages: 32
DOI: 10.2174/1568026616666160506145539
Price: $58

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