Exploring Pyrimidine Pharmacophore as Thymidine Monophosphate Kinase Inhibitors for Antitubercular Activity: A Review

Author(s): Trupti Sameer Chitre, Kalyani Dhirendra Asgaonkar, Shital Manoj Patil, Muthu Kumaradoss Kathiravan, Subhash Balkrishna Padhye.

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 28 , 2016

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Abstract:

Tuberculosis (TB) has been declared as a health emergency due to emergence of resistant strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the current situation necessitates developing new antitubercular agents acting on novel targets for effectively controlling TB. Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target, which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs reported as TMPKmt inhibitors.

Keywords: Tuberculosis, Thymidine Monophoshate Kinase (TMPKmt) inhibitors, Nucleotide, Nucleoside, Pyrimidine.

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Article Details

VOLUME: 16
ISSUE: 28
Year: 2016
Page: [3211 - 3223]
Pages: 13
DOI: 10.2174/1568026616666160506130914
Price: $58

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