Bcl-2 Family Proteins Regulate Apoptosis and Epithelial to Mesenchymal Transition by Calcium Signals

Author(s): Yanjiao Wu, Liling Tang.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 30 , 2016

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Abstract:

Intracellular Ca2+ signal plays a major role in many cellular processes, such as apoptosis and epithelial to mesenchymal transition (EMT). The role of Ca2+ in apoptotic signaling has been investigated deeply over the past few decades. In recent years, it has made progress in the interactions of intracellular Ca2+ homeostasis with EMT. Besides, Bcl-2 family proteins as versatile regulators of cell apoptosis not only regulate Ca2+ signal, but also play an important role in the induction of EMT. In this review, we summarized the relations among intracellular Ca2+ concentration, apoptosis and Bcl-2 family proteins. We also discussed the functions of intracellular Ca2+ concentration and Bcl-2 family proteins in EMT. By taking into account these analyses; we proposed a hypothesis of cell death and survival controlled by calcium signal.

Keywords: Calcium signal, apoptosis, epithelial to mesenchymal transition, EMT, Bcl-2 family proteins, cancer.

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Article Details

VOLUME: 22
ISSUE: 30
Year: 2016
Page: [4700 - 4704]
Pages: 5
DOI: 10.2174/1381612822666160506125937
Price: $58

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