Background: Silent myocardial ischemia is a recognized but suboptimally studied
condition in patients with and without known coronary artery disease. Limited work has
focused on the association between silent myocardial ischemia and future prognosis however
the majority of these analyses have focused mostly on male cohorts. As signs and symptoms
of myocardial ischemia are known to be different in women, it is important to discuss and
highlight any differences in association between silent myocardial ischemia and adverse
cardiovascular outcomes based on gender. Methods: The aim of this review is to summarize
the current literature available discussing silent myocardial ischemia and potential gender
differences. We searched English language studies on PUBMED and the Cochrane Database
of Systematic Reviews from the database start dates to November 2015. Conclusion: As
data on the presence of silent myocardial ischemia in women is limited, whether a differential
association based on gender between this condition and cardiovascular prognosis remains
unknown. Future studies should target women especially those without epicardial coronary disease and
suspected coronary microvascular dysfunction.
Keywords: Silent, ischemia, prognosis, women.
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