Natural Products as a Source for Antileishmanial and Antitrypanosomal Agents
Marcus Tullius Scotti,
Frederico Fávaro Ribeiro,
Rayssa Marques Duarte da Cruz,
Michelle Pedrosa de Oliveira,
Francisco Jaime Bezerra Mendonça.
Natural products are compounds extracted from plants, marine
organisms, fungi or bacteria. Many researches for new drugs are based on these
natural molecules, mainly by beneficial effects on health, health, efficacy, and
therapeutic safety. Leishmaniosis, Chagas disease and African sleeping sickness
are neglected diseases caused by the Leishmania and Trypanosoma ssp. parasites.
These infections mainly affect population of developing countries; they have
different symptoms, and may often lead to death. The therapeutic drugs available
to treat these diseases are either obsolete, toxic, or have questionable efficacy,
possibly through encountering resistance. Discovery of new, safe, effective, and
affordable molecules is urgently needed. Natural organisms, as marine metabolites,
alkaloids, flavonoids, steroids, terpene and coumarins provide innumerable molecules with the
potential to treat these diseases. This study examines studies of natural bioactive compounds as
antileishmanial and antitrypanosomal agents.
Keywords: Trypanossomiasis, natural products, marine metabolites, alkaloids, flavonoids, steroids, terpene, coumarins.
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