Pyrrole-2-aminoimidazole compounds are found in marine organisms, mainly as secondary
metabolites in various marine sponges. Studies of natural pyrrole-2-aminoimidazole compounds
showed that they possess different pharmacological properties, such as antimicrobial, antibiofilm, immunosuppressive
and anticancer activities. Many analogs of the natural compounds have been synthesized
to improve their biological activities. This review focuses on the antibacterial and antibiofilm potentials
of natural pyrrole-2-aminoimidazoles and their synthetic analogs and derivatives, as well as on
the structure-activity relationships of the most promising compounds. Known molecular targets of
these compounds in bacterial cells are also described here, as is the synergistic activity of the pyrrole-
2-aminoimidazoles and conventional antibiotics.
Keywords: Alkaloids, antibacterial, antibiofilm, marine organisms, oroidin, pyrrole-2-aminoimidazole, secondary metabolites.
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