Compounds with the quinoline scaffold are widely investigated and offer
a variety of therapeutical properties. A number of quinoline derivatives have been
synthesized and among these there are glycoconjugated derivatives. Based on the
interest for this family of compounds, we reviewed the different biological activities
(molecular probes, antiinfective, antiproliferative, antiaggregant and antioxidant)
and the potential applications in medicinal chemistry of quinoline glycoconjugates.
This review wants to show an example of the glycoconjugation strategy which arose
not only to modify the water solubility of the quinolines but also to influence their
activity and targeting properties.
Keywords: Aggregation, bacteria, cancer, clioquinol, glycosides, infection, malaria, sugar.
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