Mesoporous silica nanoparticles (MSNs) are exceptionally promising drug carriers for controlled
drug delivery systems because their morphology, pore structure, pore volume and pore size can
be well tailored to obtain certain drug release profiles. Moreover, they possess the ability to specifically
transport and deliver anti-cancer drugs when targeting molecules are properly grafted onto their surface.
MSNs based drug delivery systems have the potential to revolutionize cancer therapy. This review
provides a comprehensive overview of the fabrication, modification of MSNs and their applications
in tumour-targeted delivery. In addition, the characterization and analysis of MSNs with computer
aided strategies were described. The existing issues and future prospective concerning the applications
of MSNs as drug carriers for controlled drug delivery systems were discussed.
Keywords: Computational design, controlled release, mesoporous silica nanoparticles, targeted drug delivery, mesoporous silica
nanoparticles (MSN), nanocarriers.
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