Recent Advances in Methods of Puerarin Biotransformation

Author(s): Guiyou Liu, Zhonghua Liu, Sheng Yuan.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 16 , Issue 17 , 2016

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Abstract:

Puerarin is an isoflavonoid extracted from the roots of Pueraria lobata in the Pueraria thomsonii family. Puerarin displays a broad range of pharmacological activities and has been widely used in clinics. However, puerarin’s low solubility and permeability result in poor gastrointestinal absorption and low bioavailability. Simply increasing the dose does not effectively increase bioavailability and might lead to toxicity and side effects. Considerable progress has been achieved in the recent years on puerarin structural biotransformation using microorganisms and free enzymes. Increasingly numerous new puerarin derivatives with high solubility and bioactivity have been developed. This paper reviews recent progress in the biotransformation of puerarin.

Keywords: Biotransformation, Deglycosylation, Glycosylation, Hydroxylation, Puerarin, Research progress.

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Article Details

VOLUME: 16
ISSUE: 17
Year: 2016
Page: [1392 - 1402]
Pages: 11
DOI: 10.2174/1389557516666160505114456
Price: $58

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