Non-cholesterol Sterols in the Diagnosis and Treatment of Dyslipidemias: A Review

Author(s): Lucía Baila-Rueda, Ana Cenarro, Fernando Civeira.

Journal Name: Current Medicinal Chemistry

Volume 23 , Issue 20 , 2016

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Abstract:

Non-cholesterol sterols have been used as markers of cholesterol intestinal absorption and hepatic synthesis, leading to a better understanding of cholesterol homeostasis in humans. This review discusses the main noncholesterol sterols that are clinically useful, different methods to quantify the factors associated with blood concentration, and the potential role of non-cholesterol sterols in the diagnosis and treatment of different types of dyslipidemia. The main indication is the use of non-cholesterol sterols for the diagnosis of rare diseases associated with defects in cholesterol synthesis or anomalies in the absorption and/or elimination of phytosterols. However, other potential uses, including the diagnosis of certain hypercholesterolemias and the individualization of lipid-lowering therapies, are promising as they could help treat a wider population.

Keywords: Dyslipidemia, Hypercholesterolemia, Lipid-lowering therapies, Non-cholesterol sterols, Phytosterols, Plant sterols.

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Article Details

VOLUME: 23
ISSUE: 20
Year: 2016
Page: [2132 - 2145]
Pages: 14
DOI: 10.2174/0929867323666160504104133
Price: $58

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