Objective/Method: A series of 4H-chromen-4-one derivatives (A1-A16) have been designed and
synthesized, and they were screened for BRAF kinase inhibitory activity. Furthermore, their biological activities
were evaluated in vitro.
Result: Compounds A03 and A10 displayed the most potent antiproliferative activity against human osteosarcoma
cell line (U2OS) and A16 displayed the most potent antiproliferative activity against human melanoma cancer cell
line (A375) in vitro, which was valuable to study further.
Keywords: 4H-Chromen-4-one, anticancer activity, BRAF (V600E) kinase, design, in vitro, synthesis.
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