Background: Cancer is one of the most serious illnesses of our civilization.
Therefore, scientists of different disciplines try to find new treatment strategies
and new chemical molecules which might be useful in a cancer treatment.
Objective: The goal of this work is to perform the most significant achievements
in the area of chemotherapeutic treatment, published during the last two years.
Methods: We reviewed almost 80 contributions, searching for new molecules with
anticancer activity and treatment strategies.
Results: We have presented tens of new anticancer molecules interacting with
DNA or affecting cell cycle and new findings in this area. These compounds are
chemically synthesized as well as are isolated from natural sources. The discovered molecules may
induce cancer cells apoptosis, improve other cancer treatments, such as radiotherapy or reduce side
effects of chemotherapy.
Conclusion: The review shows that the cancer battle is still in progress and the combined studies in
different disciplines, devoted to this subject, are a rapidly expanding area.